natK [2017-8-11 16:0:3]

two-component sensor kinase, regulation of the natA-natB operon

locus: BSU02730

pI: 8.05

mw: 34.92 kDa

protein length: 318 aa

gene length: 954 bp

function: regulation of the natA-natB operon

product: two-component sensor kinase

essential: no

synonyms: yccG

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

Gene

Coordinates: 294,615 → 295,571

The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|D3F6337B94A633730E514B05CA852BE9AA3741B3|NatR] in response to sodium availability

[SW|Domains]

• three transmembrane segments, C-terminal histidine phosphotransferase domain

Modification

• autophosphorylation on a His residue

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]-[gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]
  description: [pubmed|22383849]

Biological materials

Mutant

• MGNA-C042 (yccG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2040 NBRP B. subtilis, Japan]

References

• 10094672,17322186